'Grey's Anatomy' ends when Ellen Pompeo quits

It is alleged, however, that Izzie was written out of the show after disagreements with the show's creator Shonda Rhimes. The 300th episode of Grey's Anatomy airs Thursday, Nov. 9 at 8 p.m. ET. Pompeo says that she's witnessed the show empower mothers to take a more active role in their children's medical care.

According to star Ellen Pompeo - who's been leading the show as Dr. Meredith Grey for 14 seasons, since its debut March 27, 2005 - fans can expect the episode to be "classic Grey's".

On November 9, Ellen Pompeo begins the day live in studio in NY at "Good Morning America" and then segues over to "Live with Kelly and Ryan" where she'll talk about playing the iconic Dr. Meredith Grey for 14 seasons. Also, Mer found inspiration through a new medical procedure while Jo found the courage to finally get a divorce from her abusive ex so that she could finally begin to move forward with her life and stop hiding.

Over the years we have covered many aspects of the show from the best sex scenes to the doctors that left the show and the worst spoiler alert ever when Derek's death (sorry, may still be a spoiler for some) was announced before many people had the chance to watch the highly anticipated episode.

"We historically have always carried the past with us season after season", Wilson says. So I don't know if we'll see 600, but I want to keep it feeling fresh.

"As long as there are fresh stories to tell and as long as we're both excited about the stories being told, we're in", she said.

When we last left off on Grey's Anatomy, Jackson chose to buy a yacht with some of his inheritance money and promptly christened his new ship by inviting Alex, Owen, DeLuca and Ben to join him for a day at sea shooting back beers and relaxing - while also talking through their respective problems, of course! When do you think the show will end?

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