Instant reaction to Dolphins' 45-21 loss to the Panthers

Jeremy Brevard-USA TODAY Sports

Newton completed 21 of his 35 attempts to seven different receivers. The veteran running back ran for a game-high 110 yards on 17 carries.

Carolina's 548 total yards marked a franchise record.

The Dolphins still don't have a rushing touchdown this season and didn't have a run longer than 5 yards on Monday until there were six minutes remaining in the first half. Miami answered on a shovel pass from Jay Cutler to Julius Thomas to cut the lead back to three.

Carolina got the ball back by stopping Miami's fourth-and-1 play from the Dolphins' 49.

The Dolphins' run defense, which entered the game allowing just 94 yards per game, 10th-fewest in the National Football League, was trampled for a season-worst 294 yards, besting the previous worst (174 by Baltimore) by a sizeable margin.

The Dolphins showed life when Kenyan Drake went 66 yards for a touchdown on a third-down run.

When Carolina Panthers quarterback Cam Newton was flat on his back in 2016, it was nearly always to clear his head after he'd been decked in the pocket, which was among the lasting images of the post-Super Bowl season.

The Panthers led, 17-7, at halftime, and rolled up 27 more points in the second half.

The Dolphins' big blunder in the first half was Cutler's interception with 47 seconds left. With an unsportsmanlike conduct penalty tacked on, it gave Carolina possession at the Miami 20.

Newton threw his first touchdown pass of the game in the second quarter to Ed Dickson, before finding Devin Funchess, McCaffrey, and Funchess again before the night was out.

After a pair of powerful statements from the defending conference champion Atlanta Falcons and the division-leading New Orleans Saints, the Carolina Panthers couldn't afford to fall flat on Monday night. He had a would-be first-quarter interception overturned by video review.

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