Novartis aims to broaden use of breast cancer drug

Dutch cancer survival rates have risen sharply since the 1960s

"However, these initial results are very exciting".

Women who choose to be apart of the WISDOM study have to be a Sanford patient, between the ages of 40 to 74, with no history of breast cancer. "A significant amount of preclinical and correlative clinical data suggest that such cases could be amenable to immunotherapy".

Ribociclib is beneficial for pre- and perimenopausal women with hormone receptor positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC), according to a study presented at the annual San Antonio Breast Cancer Symposium, held from December 5 to 9 in Texas. "Moreover, the quantification of TILs seems to be a meaningful way for us to identify those who would benefit most from an immunotherapeutic approach". Previous, smaller studies have shown that acupuncture can reduce joint pain and swelling related to aromatase inhibitor treatment, according to Dr. Hershman, but these studies provided uncertain interpretations due to their small size and the fact that they were conducted at single institutions. The researchers used the patients' reported "worst pain" as the primary endpoint measure. Of the patients in the study, 110 received true acupuncture, 59 were given fake acupuncture - needles placed at ineffective spots on the body - and another 57 were placed on a waiting list.

After six weeks, patients in the true acupuncture group reported much lower pain scores than those in either the fake acupuncture or waiting list groups, Hershman's team reported.

"If something so simple as acupuncture can improve upon these symptoms and the patients' quality of life, we will have more women becoming compliant in taking their medication, and one would expect improved outcomes", Cassell added.

For more from Rare Disease Report, follow along on Facebook and Twitter. There are agents in many settings that are being investigated in combination, says Rimawi, which will hopefully benefit more patients with breast cancer.

"Our goal was to provide an alternative to pain medications to control this side effect", said Dr. Hershman. That's what we would like to see, but, again, you can't really predict that.

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