Being dependent on oral antibiotics? It may up kidney stones risk

Supported by Antibiotics May Raise the Risk for Kidney Stones By Nicholas Bakalar

It showed patients who took oral antibiotics were more likely to develop kidney stones up to fie years later. In such cases, a urologist may need to remove the kidney stones or break them into smaller pieces.

After controlling for urinary tract infections, medications, diseases like gout and diabetes, and other variables, they found that exposure to any of five classes of antibiotics significantly increased the risk for kidney stones.

"Our findings suggest that antibiotic prescription practices represent a modifiable risk factor - a change in prescribing patterns might decrease the current epidemic of kidney stones in children", said the study's lead, Dr Gregory E Tasian. The disorder of microbial communities can then lead to easier kidney stone formation. Around 30 percent of the prescribed antibiotic files are not the right medication according to Tasian.

"I think this is the tip of the iceberg", Tasian says. The condition is, however, associated with bacterial changes in the intestines and urinary tract, leading investigators to study the relationship between antibiotics and kidney stones.

Now, that the link has been established between antibiotics and stones. The results of their study appeared in the Journal of the American Society of Nephrology. While diet trends, such as more soda and caffeine, and less water are likely factors, the doctor's team made a decision to look at common medications, like antibiotics, which are prescribed to children much more than adults. They narrowed the sample to nearly 26,000 patients diagnosed with kidney stones, and a control group of almost 260,000 people without kidney stones. Risks were increased 2.3 times, 1.9 times, 1.7 times, 1.7 times, and 1.3-times for sulfas, cephalosporins, fluoroquinolones, nitrofurantoin/methenamine, and broad-spectrum penicillins, respectively. In exploratory analyses, the magnitude of associations was greatest for exposure at younger ages (P 0.001) and 3-6 months before index date (P 0.001), with all but broad-spectrum penicillins remaining statistically significant 3-5 years from exposure.

It is still unknown why kidney stones are on a hike these days but according to the study, consuming antibiotics certainly play a major role when it comes to prescribing them to children more than that of adults.

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